Rexilo 120mg Tablet

Uses of Rexilo 120mg Tablet

• Treat advanced prostate cancer

How does Rexilo 120mg Tablet work?

Relugolix tablets work by decreasing the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread of prostate cancer cells that need testosterone to grow.

Side Effects of Rexilo 120mg Tablet

• hot flashes
• skin flushing
• sweating
• weight gain
• decreased sexual desire or ability
• muscle, back, joint, or bone pain
• fatigue
• diarrhea
• constipation
• difficulty falling asleep or staying asleep
• depression
• enlargement of the breasts

How should I take Rexilo 120mg Tablet?

Take Rexilo 120mg Tablet as advised by your physician. Swallow with a glass of water and do not chew or crush it. Your doctor will decide the correct dose and duration of Rexilo 120mg Tablet treatment for you depending on your age, body weight, and disease condition. Do not stop taking Rexilo 120mg Tablet unless your doctor advises you to stop.

Quick Suggestions:

• Take Rexilo 120mg Tablet exactly as prescribed by your doctor. Follow all the instructions on the prescription label and medication guides.
• The usual dosing regimen forRexilo 120mg Tablet is 3 tablets on the first day, followed by 1 tablet per day thereafter.
• Take the tablets at the same time each day, with or without food.
• Swallow the tablet whole and do not crush, chew, or break it.
• Be prepared for frequent medical tests, as your doctor may need to monitor your heart function using an electrocardiogram (ECG or EKG).
• The duration of your treatment with Rexilo 120mg Tablet will be determined by your doctor. Do not change your dosage or stop using the medicine without consulting your doctor.

Indication

Calutide 50 mg Tablet is a non-steroidal anti-cancer medicine used in men along with other specific agents for the treatment of prostate cancer. This medicine is not recommended for use in females, children, and adolescents.

Pharmacology

Rexilo 120mg Tablet is an anti-androgen medication that exerts its pharmacological effects by inhibiting the action of androgens, which are male sex hormones responsible for the growth and development of the prostate gland. Prostate cancer cells depend on androgens to grow and spread, so by blocking the androgen receptors, Rexilo 120mg Tablet prevents the cancer cells from receiving the signals that promote their growth.

By inhibiting the androgen receptors, Rexilo 120mg Tablet slows down the growth of prostate cancer cells and reduces their ability to spread to other parts of the body. This action helps in controlling the progression of prostate cancer and alleviating the symptoms associated with it.

The drug is usually taken orally as a tablet, and its effects are specific to androgen receptors in the prostate gland, sparing other tissues from similar inhibition. Rexilo 120mg Tablet works alongside other treatments for prostate cancer to improve outcomes and quality of life for patients with this condition. However, it is essential to follow the prescribed dosage and consult the doctor regularly for monitoring and adjusting the treatment plan as necessary.

Dosage & Administration of Rexilo 120mg Tablet

• Relugolix is available in tablet form and should be taken orally. It can be taken with or without food once daily, at approximately the same time each day.
• Follow your doctor's instructions carefully and ask your pharmacist or doctor for clarification if needed.
• Take Rexilo 120mg Tablet exactly as prescribed; do not take more or less or take it more frequently than directed.
• Swallow the tablets whole; do not crush, chew, or split them.
• For more detailed information about Rexilo 120mg Tablet, you can ask your pharmacist or doctor for a copy of the manufacturer's patient information leaflet.
• This will provide you with additional important information about the medication.

Interaction

When taking Relugolix, it is important to be cautious about potential drug interactions. Some medications may affect the blood levels of Relugolix, leading to increased side effects or reduced effectiveness. In particular,Relugolix can cause a serious heart problem, and the risk may be higher when combined with certain other medications used for various conditions.

To minimize the risk of interactions, certain drugs should not be taken within 6 hours after you take Relugolix. It is crucial to carefully follow your doctor's instructions regarding the scheduling of all your medications. Always inform your doctor about all the medications you are taking, including prescription and over-the-counter medicines, vitamins, and herbal products, to avoid any harmful interactions. Your doctor can assess the potential interactions and adjust your treatment plan accordingly to ensure your safety and optimal treatment outcomes.

Contraindications

Before starting relugolix, it's crucial to consider the following:

• Do not take relugolix if you have a history of heart problems or long QT syndrome in you or a family member.
• Relugolix can cause harm to an unborn baby and may lead to a miscarriage. If you are a man and your partner can become pregnant, use effective birth control during treatment and for at least 2 weeks after the last dose.
• Inform your doctor if your partner is pregnant or planning to become pregnant.

It's important to communicate with your doctor about any pre-existing conditions or potential risks before using this medication. Following your doctor's advice and using appropriate birth control methods can help ensure the safe and effective use of relugolix.

Pregnancy & Lactation

This drug has shown embryo-fetal lethality in animal studies at maternal exposures 0.3 times the human exposure at the recommended dose of 120 mg daily, based on AUC. There are no controlled data on human pregnancy.

The US FDA has not assigned a specific pregnancy category for this drug. Safety and efficacy during pregnancy have not been established. Patients should be aware that this drug can cause fetal harm and loss of pregnancy based on animal studies and its mechanism of action. Therefore, it is important to advise patients of the potential risk to the fetus.

This drug may also impair fertility. Males with female partners of reproductive potential should use effective contraception during therapy and for at least 2 weeks after the last dose.

Regarding lactation, it is unknown whether this drug is excreted into human milk. In animal studies, the drug and its metabolites were present in the milk of lactating animals, with concentrations up to 10-fold higher than in plasma at 2 hours post-dose after a single oral dose of 30 mg/kg on post-partum day 14. The effects in nursing infants are unknown, and there is no specific recommendation for use during breastfeeding.

Because the drug is approximately 68 to 71% bound to plasma proteins and has a half-life of about 25 hours, it may accumulate in the infant if excreted into breast milk. Further research is needed to understand the potential risks to nursing infants.

Precaution & Warnings:

• Before taking relugolix, it is essential to inform your doctor and pharmacist about any allergies you may have, including allergies to medications and other substances. If you are unsure about the ingredients in relugolix tablets, ask your pharmacist for a list.
• Make sure to provide a complete list of all prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to adjust the doses of your medications, temporarily stop certain treatments, or closely monitor you for potential side effects.
• Inform your doctor if you or anyone in your family has a history of long QT syndrome, which is a rare heart condition that can cause irregular heartbeats, fainting, or sudden death. Also, disclose any history of electrolyte imbalances in your blood, heart failure, diabetes, high triglycerides, anemia, or liver problems.
• It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.
• Keep in mind that relugolix is intended for use in men only and is not to be used alone in women. If you are a male and your female partner can become pregnant, it is crucial to use effective contraception during treatment and for 2 weeks after the last dose, as relugolix may harm the fetus.
• It's important to note that relugolix may also reduce fertility in men. Discuss any concerns or questions you have regarding the potential risks of taking relugolix with your doctor.

Storage Conditions

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (small packet included with medication to absorb moisture).